23 research outputs found
E/BD in Inclusive Classrooms (Grades P-3)
This meta-synthesis focuses on the literature pertaining to students with emotional and behavioral disorders in inclusive preschool through third grade classrooms. The first purpose of this study was to discover the feelings and ideas that teachers, parents and community members have. Teachers, parents and community members have varying views about inclusion of students with emotional and behavioral disorders. The second purpose was to discover ideas that teachers could use in the classroom to successfully support students with emotional and behavioral disorders
The kinematic and thermohaline zonation of the Antarctic Circumpolar Current at Drake Passage
The waters of the Antarctic Circumpolar Current at Drake Passage show mesoscale horizontal zonation into four water mass regimes horizontally separated by three fronts. Vertical profiles of T, S and O2 on opposite sides of each front are described and compared. Although the surface waters are significantly different across fronts, the vertical profiles from the same side of a specific front are remarkably uniform from year to year and from cruise to cruise...
Concert recording 2016-04-16
[Track 01]. Meditation no. 1 / Casey Cangelosi -- [Track 02]. Into the air / Ivan Trevino -- [Track 03]. Ku-ka ilimoku / Christopher Rouse -- [Track 04]. Good vibes / Oscar Hernandez -- [Track 05]. Arabesque no. 2 / Claude Debussy ; arranged by Evans -- [Track 06]. The odyssey, according to Penelope. Afternoon at the park ; [Track 07]. Toddling waltz ; [Track 08]. Babble songs ; [Track 09]. Naptime prelude ; [Track 10]. Run amok rondo / Kevin Bobo -- [Track 11]. Tiger dance / Jeffery Dennis Smith
The contribution of geogenic particulate matter to lung disease in indigenous children
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02–3.06]) and lower (OR 1.99 95% CI [1.08–3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20–7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high
Stream denitrification across biomes and its response to anthropogenic nitrate loading
Author Posting. © The Author(s), 2008. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature 452 (2008): 202-205, doi:10.1038/nature06686.Worldwide, anthropogenic addition of bioavailable nitrogen (N) to the
biosphere is increasing and terrestrial ecosystems are becoming increasingly N
saturated, causing more bioavailable N to enter groundwater and surface waters.
Large-scale N budgets show that an average of about 20-25% of the N added to the
biosphere is exported from rivers to the ocean or inland basins, indicating
substantial sinks for N must exist in the landscape. Streams and rivers may be
important sinks for bioavailable N owing to their hydrologic connections with
terrestrial systems, high rates of biological activity, and streambed sediment
environments that favor microbial denitrification. Here, using data from 15N
tracer experiments replicated across 72 streams and 8 regions representing several
biomes, we show that total biotic uptake and denitrification of nitrate increase with
stream nitrate concentration, but that the efficiency of biotic uptake and
denitrification declines as concentration increases, reducing the proportion of instream
nitrate that is removed from transport. Total uptake of nitrate was related
to ecosystem photosynthesis and denitrification was related to ecosystem
respiration. Additionally, we use a stream network model to demonstrate that
excess nitrate in streams elicits a disproportionate increase in the fraction of nitrate
that is exported to receiving waters and reduces the relative role of small versus
large streams as nitrate sinks.Funding for this research was provided by the National Science
Foundation
A descriptive study of the zonation of the Antarctic Circumpolar Current and its relation to wind stress and ice cover
Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Bibliography: leaves 89-92.Not availabl
PSMA-targeted SPECT agents: mode of binding effect on in vitro performance
The enzyme-biomarker prostate-specific membrane antigen (PSMA) is an active target for imaging and therapeutic applications for prostate cancer. The internalization of PSMA has been shown to vary with inhibitors' mode of binding: irreversible, slowly reversible, and reversible.
In the present study, PSMA-targeted clickable derivatives of an irreversible phosphoramidate inhibitor DBCO-PEG(4) -CTT-54 (IC(50) = 1.0 nM) and a slowly reversible phosphate inhibitor, DBCO-PEG(4) -CTT-54.2 (IC(50) = 6.6 nM) were clicked to (99m) Tc(CO)(3) -DPA-azide to assemble a PSMA-targeted SPECT agent. The selectivity, percent uptake, and internalization of these PSMA-targeted SPECT agents were evaluated in PSMA-positive and PSMA-negative cells.
In vitro studies demonstrated that PSMA-targeted SPECT agents exhibited selective cellular uptake in the PSMA-positive LNCaP cells compared to PSMA-negative PC3 cells. More importantly, it was found that (99m) Tc(CO)(3) -DPA-DBCO-PEG(4) -CTT-54 based on an irreversible PSMA inhibitor core, exhibited greater uptake and internalization than (99m) Tc(CO)(3) -DPA-DBCO-PEG(4) -CTT-54.2 constructed from a slowly reversible PSMA inhibitor core.
We have demonstrated that a PSMA-targeted SPECT agent can be assembled efficiently using copper-less click chemistry. In addition, we demonstrated that mode of binding has an effect on internalization and percent uptake of PSMA-targeted SPECT agents; with the irreversible targeting agent demonstrating superior uptake and internalization in PSMA+ cells. The approach demonstrated in this work now supports a modular approach for the assembly of PSMA-targeted imaging and therapeutic agents
Development of Inhibitor-Directed Enzyme Prodrug Therapy (IDEPT) for Prostate Cancer
Prostate
cancer (PCa) is the second most common cause of cancer
death among American men after lung cancer. Unfortunately, current
therapies do not provide effective treatments for patients with advanced,
metastatic, or hormone refractory disease. Therefore, we seek to generate
therapeutic agents for a novel PCa treatment strategy by delivering
a suicide enzyme (yCD<sub>triple</sub>) to a cell membrane bound biomarker
found on PCa cells (prostate-specific membrane antigen (PSMA)). This
approach has resulted in a new PCa treatment strategy reported here
as inhibitor-directed enzyme prodrug therapy (IDEPT). The therapeutic
agents described were generated using a click chemistry reaction between
the unnatural amino acid (<i>p</i>-azidophenylalanine (<i>p</i>AzF)) incorporated into yCD<sub>triple</sub> and the dibenzylcyclooctyne
moiety of our PSMA targeting agent (DBCO-PEG<sub>4</sub>-AH<sub>2</sub>-TG97). After characterization of the therapeutic agents, we demonstrate
significant PCa cell killing of PSMA-positive cells. Importantly,
we demonstrate that this click chemistry approach can be used to efficiently
couple a therapeutic protein to a targeting agent and may be applicable
to the ablation of other types of cancers and/or malignancies